No. 2 looked more like No. 1 on Saturday night.
Second-ranked LSU pulled away from No. 16 West Virginia for a 47-21 victory, the Tigers' third decisive win away from home this season.
Meanwhile, No. 1 Oklahoma fell behind early and withstood a late push from Missouri to come away with a 38-28 victory.
Ryan Broyles finished with 13 receptions for 154 yards and three touchdowns for the Sooners, who have been No. 1 since the preseason, but might be looking at relinquishing that to LSU.
The Tigers' defense allowed 463 passing to Geno Smith, but also forced four turnovers and got a 99-yard kickoff return for a touchdown from Morris Claiborne.
Oklahoma had 37 first-place votes in the AP Top 25 last week to LSU's 14.
No. 1 Oklahoma 38, Missouri 28
NORMAN, Okla. (AP) — Landry Jones threw for 448 yards and three touchdowns to Ryan Broyles, leading Oklahoma back from a rare home deficit.
With two starting receivers out of the lineup, Broyles had to play up to his usual All-American standard without proven sidekicks. Kenny Stills, who caught the go-ahead touchdown in a win at then-No. 5 Florida State last week, was out with a head injury and Trey Franks is suspended indefinitely.
The Sooners roared back with 28 straight points to avenge a loss in Columbia last year when they were first in the BCS standings and move their home winning streak to 38 straight games.
The Tigers (2-2, 0-1 Big 12) pounced early to take a 14-3 first-quarter lead, breaking a streak of 20 straight home games in which Oklahoma (3-0, 1-0) never trailed.
No. 2 LSU 47, No. 16 West Virginia 21
MORGANTOWN, W.Va. (AP) — Jarrett Lee threw three touchdown passes, Michael Ford ran for two scores and LSU beating West Virginia.
The Tigers (4-0) converted two turnovers into scores, built a big early lead and withstood West Virginia's strong comeback for its third win over a ranked opponent this season, with all of three coming away from home. Every win so far has been by double digits.
Lee's three TD passes tied a career high and matched his output of the three previous games. He finished 16 of 28 for 180 yards.
West Virginia (3-1) outgained LSU 533-366. West Virginia's Geno Smith set school records for completions (38), attempts (65) and passing yards (463). But he was intercepted twice after making one in the previous three games.
No. 3 Alabama 38, No. 14 Arkansas 14
TUSCALOOSA, Ala. (AP) — The Crimson Tide scored on special teams, defense and using the old-fashioned power run to emphatically win the SEC West showdown.
AJ McCarron completed 15 of 20 passes for 200 yards and two touchdowns, including a 37-yard TD pass to Michael Williams on a fake field goal for the Tide (4-0, 1-0 Southeastern Conference).
Marquis Maze scored on an 83-yard punt return and DeQuan Menzie returned an interception 25 yards for another score.
Tyler Wilson sat out most of the fourth quarter after completing 22 of 35 passes for 185 yards and two touchdowns for Arkansas (3-1, 0-1).
No. 4 Boise State 41, Tulsa 21
BOISE, Idaho (AP) — Kellen Moore tossed four touchdown passes, a pair to Tyler Shoemaker, in less than 2 1/2 quarters and Jerrell Givens had two interceptions for Boise State in its home opener.
The Broncos (3-0) won their 33rd consecutive regular season home game and led 27-0 at the break.
Tulsa (1-3) concluded a brutal early season stretch that featured a game at No. 1 Oklahoma and last week's wacky 59-33 loss at home to No. 7 Oklahoma State that didn't kickoff until after midnight early Sunday morning.
No. 6 Wisconsin 59, South Dakota 10
MADISON, Wis. (AP) — Nick Toon had a career-high 155 yards receiving and two touchdowns in Wisconsin's final tune-up for Nebraska at Camp Randall next week.
Wisconsin (4-0) recovered from a slow start to take control of the game with a 21-point outburst in the final six minutes of the second quarter.
James White had a 49-yard touchdown run, Toon scored on a 59-yard catch-and-run from quarterback Russell Wilson and Toon added another score with 12 seconds left to send Wisconsin into halftime with a 31-3 lead.
Wilson had another big day for the Badgers, completing 19 of 25 passes for 345 yards and three touchdowns before taking a seat in the fourth quarter.
Quarterback Dante Warren struggled for South Dakota (2-2), a Football Championship Subdivision school. He eventually was replaced by Josh Vander Maten, who led the Coyotes to a late score.
No. 9 Nebraska 38, Wyoming 14
LARAMIE, Wyo. (AP) — Rex Burkhead rushed for two touchdowns and a career-high 170 yards, Taylor Martinez threw for 157 yards and a score to lead Nebraska.
The Huskers (4-0) rolled up 490 yards total offense, including 333 on the ground, in their first road game of the season and last game before their highly anticipated Big Ten opener at Wisconsin next weekend.
Burkhead had TD runs of 45 and 16 yards. He carried the ball 15 times for an average of 11.3 yards per rush. His previous career rushing high was 129 yards against Iowa State in 2010.
Wyoming (3-1) was led by quarterback Brett Smith, who passed for 166 yards and two scores.
No. 21 Clemson 35, No. 11 Florida State 30
CLEMSON, S.C. (AP) — Tajh Boyd threw for three touchdowns and ran for another as Clemson opened Atlantic Coast Conference play with a victory.
Boyd threw for 344 yards for the Tigers, who reached 4-0 for the first time since 2007. Freshman Sammy Watkins had two of Boyd's scoring passes for 24 and 62 yards as Clemson beat the Seminoles (2-2, 0-1) for the fifth straight time in Death Valley.
Watkins finished with eight catches for 141 yards, his second consecutive 100-yard receiving game.
Florida State played without starting quarterback EJ Manuel, hurt in last week's 23-13 loss to top-ranked Oklahoma. Backup Clint Trickett kept the Seminoles in this, though, with 336 yards and three touchdown passes.
No. 12 South Carolina 21, Vanderbilt 3
COLUMBIA, S.C. (AP) — Marcus Lattimore scored two touchdowns and had 150 total yards from scrimmage to lead South Carolina.
The Gamecocks (4-0, 2-0 Southeastern Conference) won on defense, holding the Commodores (3-1, 1-1) to 77 yards.
South Carolina is 4-0 for the first time in coach Steve Spurrier's seven years with the team.
Stephen Garcia threw four interceptions for South Carolina, but defensive end Melvin Ingram has scored his third TD of the season. Ingram recovered a teammate's fumble in the end zone to go with two sacks, a tackle for an 8-yard loss and swatted away a pass.
No. 13 Virginia Tech 30, Marshall 10
HUNTINGTON, W.Va. (AP) — David Wilson rushed for 132 yards, Josh Oglesby scored two touchdowns and Virginia Tech won its final tuneup before opening Atlantic Coast Conference play against Clemson.
It was another lackluster win over an opponent from a non-BCS conference for the Hokies, who are off to their first 4-0 start since 2006.
Virginia Tech displayed some big-play ability and kept the turnover-prone Thundering Herd (1-3) in their own end for much of the game. But Marshall continued to expose Tech's vulnerabilities in the worrisome way East Carolina and Arkansas State did earlier this season.
No. 15 Florida 48, Kentucky 10
LEXINGTON, Ky. (AP) — Jeff Demps ran 10 times for 157 yards and two touchdowns as Florida beat Kentucky for the 25th straight time.
Florida (4-0, 2-0 Southeastern Conference) scored three touchdowns in a 4:31 span during the first quarter, taking advantage of two turnovers by Kentucky (2-2, 0-1). Trey Burton had a 1-yard touchdown run that put the Gators up 21-0.
Demps had an 84-yard touchdown run, Florida's longest since Emmitt Smith's 96 yarder against Mississippi State in 1988. Chris Raney added 105 yards, and John Brantley was 8 for 14 for 115 yards and a score.
Kentucky's lone touchdown came after an interception thrown by backup Florida quarterback Jeff Driskel. Morgan Newton, who was 16-of-33 for 124 and two interceptions, threw a 19-yard touchdown pass to La'Rod King with 1:18 before halftime to cut the Gators' lead to 31-10.
No. 17 Baylor 56, Rice 31
WACO, Texas (AP) — Robert Griffin III threw five touchdown passes and ran for another score to lead Baylor.
Griffin was 29 of 33 for 338 yards, upping his season totals to 13 touchdowns and 12 incompletions, and he didn't play in the fourth quarter. He came into the game leading the nation in passing efficiency and third in total yards.
Further boosting his Heisman Trophy credentials, Griffin ran for 51 yards and even punted once, on a quick kick, for 39 yards. His TD throws were caught by five different receivers.
Griffin led Baylor to touchdowns on five straight drives in the first half, putting the Bears (3-0) ahead 35-7.
The Owls (2-1) were coming off a win against Purdue, their first against a team from a BCS conference since 2001.
No. 18 USF 52, UTEP 24
TAMPA, Fla. (AP) — B.J. Daniels threw for 202 yards and ran for 130 more for South Florida (4-0).
Daniels scored on a 71-yard run on the Bulls' second offensive play and threw touchdown passes of 54 and 18 yards to Lindsey Lamar in the second half. The junior's long TD burst was the fourth-longest in USF's relatively brief football history, and receiver Victor Marc's 67-yard scoring run later in the opening quarter was the fifth-longest.
UTEP (2-2) played without several key players sidelined with injuries, including starting quarterback Nick Lamaison, safety Travaun Nixon and defensive lineman Germard Reed.
No. 20 TCU 55, Portland State 13
FORT WORTH, Texas (AP) — TCU scored three touchdowns in a span of 1:18 just before halftime and Waymon James ran 65 yards for a score on the first play of the second half as the Horned Frogs won easily.
The Horned Frogs (3-1) extended a school record with their 22nd consecutive win at home. But they were still tied 3-3 with the lower-division FCS team until finally busting loose just before halftime.
Casey Pachall threw a short pass to Josh Boyce, who turned upfield to find a wide-open lane for a 66-yard touchdown with 1:55 left.
Portland State (1-2) took only one snap after that before Tank Carder's 26-yard interception return for a TD. After the Vikings went three-and-out on their next possession, Skye Dawson followed his 42-yard punt return with a 10-yard TD catch for a 24-3 halftime lead.
James also had an 82-yard kickoff return for a score.
No. 22 Michigan 28, San Diego State 7
ANN ARBOR, Mich. (AP) — Denard Robinson ran for a season-high 200 yards and three touchdowns to lead the Wolverines past Michigan coach Brady Hoke's former team.
Robinson ran 21 times and reached 200 yards rushing for the third time in his career for Michigan (4-0). He matched his career high with three rushing scores and did it in one half for the first time.
San Diego State (3-1) had won its first three games for the first time since 1981, Ryan Lindley and the offense started slowly against Michigan. Lindley completed 23 of 48 passes for 253 yards and a TD. Ronnie Hillman ran for 109 yards on 21 carries.
No. 24 Illinois 23, Western Michigan 20
CHAMPAIGN, Ill. (AP) — Troy Pollard ran for a career-high 133 yards and Derek Dimke kicked three field goals as Illinois survived.
The Illini trailed at the half 13-10 and the game was tied 20-20 with less than nine minutes to play. Booing Illini fans recalled a 23-17 loss to the Broncos (2-2) the last time the teams met in 2008.
Pollard's 49-yard burst midway through the fourth quarter set up a 21-yard Dimke field goal that gave the Illini (4-0) the three-point lead they wouldn't give up.
Alex Carder was 30 of 48 with two touchdowns, 306 yards and one interception. His second-quarter scoring pass to Chleb Ravenell gave the Broncos their halftime lead. Jordan White caught 14 passes for 132 yards and a third-quarter touchdown that tied the game at 20.
No. 25 Georgia Tech 35, North Carolina 28
ATLANTA (AP) — Tevin Washington threw a long touchdown pass and ran for two scores, including a 5-yarder that gave Georgia Tech a 4-0 start.
The Tar Heels (3-1, 1-1 ACC) fought back from a 28-14 deficit, tying the game on freshman Giovani Bernard's 55-yard run with 7:22 left. Georgia Tech (4-0, 1-0) needed only four plays to respond.
Roddy Jones reached out to take a pitch from Washington that looked too far in front of the running back, going 48 yards down the sideline to the North Carolina 9. Two snaps later, Washington took it in for the winning score with 5:20 left.
Stephen Hill had a huge game for Georgia Tech with six receptions for 151 yards, including a 59-yard touchdown. Bernard rushed for 155 yards and two TDs.
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